شیوع آلودگی به هلیکوباکتر پیلوری و فاکتورهای خطر بیماری‌های قلبی و عروقی با وجود عوامل زمینه ساز آترواسکلروز در افراد مبتلا به بیماری‌های قلبی و عروقی

Abstract Background & Aims: Atherosclerosis is the main reason of cardiovascular diseases, and risk factors incorporated in atherosclerosis involvement include infections like Helicobacter pylori. In the current study the incidence of contamination to Helicobacter pylori, atherosclerosis causing factors, and the effect of these factors on the serum levels of lipids and lipoproteins are studied. Materials & Methods: Along with determination of H. pylori infection, serum level of triglyceride, cholesterol, LDL-C, HDL-C, vLDL-C and cholesterol/HDL-C ratio were also identified in 100 patients with cardiovascular atherosclerosis and 89 healthy people as the control group. Results: Sera of 68% of patients and 49.5% of control group were positive for H. pylori infection (P0.05). There was a significant difference in serum levels of lipids and lipoproteins between the patients and the control groups (P<0.05). The results of this study after measurement of H. pylori specific IgG level showed that there was a significant difference in the H. pylori infection rate between the cardiovascular atherosclerosis patients with and without gastric disease (P<0. 05). Conclusion: The results of this study showed that among incorporating factors, seroprevalence of H. pylori specific IgG was higher in patients with gastric disease history than that in the control group, indicating that gastric diseases could incorporate in atherum creation and eventually cardiovascular disorders. Regarding to incoherent results of various studies, there is a necessity to determine the effects of H. pylori on cardiovascular disorders involvement risk. To find the real relationship between H. pylori infection and cardiovascular disease risk factors may be an important challenge to diminish cardiovascular disease involvement rate. Keywords: Helicobacter pylori, atherosclerosis, lipids, cardiovascular disease Address: Biochemistry Department, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Tel: (+98441) 2770969 Email: [email protected] Source: Urmia Med J 2010: 21(1): 098 ISSN: 1027-3727